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KMID : 0960920030020010017
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Dementia and Neurocognitive Disorders
2003 Volume.2 No. 1 p.17 ~ p.22
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Relationship between Different Brain Regions in Hierarchial Order of Neurofibrillary Tangles and Senile Plaques in Alzheimer Brain
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Jeong Jee-Hyang
Park Kee-Duk
Choi Kyoung-Gyu
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Abstract
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Background: Neurodegenerative process in AD is characterized by progressive neuronal and synaptic loss with gliosis and formation of senile plaque and neurofibrillary tangles. Relationship between severity of NFTs and SPs has still intriguing aspect.
Methods: Hierarchial rank order of NFT and SPs was done instead of absolute morphometric quantitation to find out severity of each pathologic changes in regions of frontal, temporal, hippocampus, amygdala, entorrhinal cortex, piriform cortex, basal nucleus of Meynert (BNM), substantia nigra and locus coeruleus. Also age and brain weight were analyzed to find out relationship to each region.
Results: Weight of brain showed significant correlation with neuronal loss in frontal, temporal and BNM but
it did not show any correlation with the neuronal loss in LC, SN and amygdala. In amygdala NFT were high in cortical and cortical transitional nuclei. SPs were heavily accumulated in basomedial, cortical and cortical transitional nuclei. In hippocampus, entorrhinal cortex, H1 and subiculum of the hippocampus were the most consistent and severely affected regions. BNM did not show any correlation with laterobasal nucleus of amygdala which projects to BNM. SN, LC as well as BNM were interrelated in the severity of these changes. Nevertheless, these changes were not correlated with the brain weight.
Conclusion: Different regional vulnerability even in a single area is demonstrated in a hierarchial order. But it is still a perpetuating question how these regional vulnerability occurs.
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KEYWORD
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Alzheimer’s disease, Neurofibrillary tangle, Senile plaque
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